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1.
Sci Rep ; 12(1): 13971, 2022 08 17.
Article in English | MEDLINE | ID: covidwho-2016825

ABSTRACT

A comprehensive study of the properties of finite (0,1) binary systems from the mathematical viewpoint of quantum theory is presented. This is a quantum-inspired extension of the GenomeBits model to characterize observed genome sequences, where a complex wavefunction [Formula: see text] is considered as an analogous probability measure and it is related to an alternating (0,1) binary series having independent distributed terms. The real and imaginary spectrum of [Formula: see text] vs. the nucleotide base positions display characteristic features of sound waves. This approach represents a novel perspective for identifying and "observing" emergent properties of genome sequences in the form of wavefunctions via superposition states. The motivation is to develop a simple algorithm to perform wave calculations from binary sequences and to apply these wave functions to sonification.


Subject(s)
Algorithms , Quantum Theory , Genome
2.
PLoS One ; 17(7): e0271039, 2022.
Article in English | MEDLINE | ID: covidwho-1928287

ABSTRACT

We apply the new GenomeBits method to uncover underlying genomic features of omicron and delta coronavirus variants. This is a statistical algorithm whose salient feature is to map the nucleotide bases into a finite alternating (±) sum series of distributed terms of binary (0,1) indicators. We show how by this method, distinctive signals can be uncovered out of the intrinsic data organization of amino acid progressions along their base positions. Results reveal a sort of 'ordered' (or constant) to 'disordered' (or peaked) transition around the coronavirus S-spike protein region. Together with our previous results for past variants of coronavirus: Alpha, Beta, Gamma, Epsilon and Eta, we conclude that the mapping into GenomeBits strands of omicron and delta variants can help to characterize mutant pathogens.


Subject(s)
Coronavirus , Coronavirus/genetics , Spike Glycoprotein, Coronavirus/genetics
3.
International Journal of Emerging Technologies in Learning (Online) ; 16(21):201-209, 2021.
Article in English | ProQuest Central | ID: covidwho-1857024

ABSTRACT

A main step for world's progress is to keep sharing ever-present Ideals for science and education within today's Virtual Realities. On-line education is transforming human society to new levels in the way people teach and learn during the ongoing SARS-CoV-2 pandemic. There is an increasing interest in having more and more reliable, fast and simple apps to communicate and also to record, assemble and distribute videos and lectures in the fields of Physics & Maths still using traditional didactic methods. We describe here how to accurately reproduce chalkboard classes for the popular YouTube video platform using OpenEyA-YT. The audience can thus be expanded over continents to help mitigate the effects of physical isolation.

4.
Genes (Basel) ; 12(7)2021 06 25.
Article in English | MEDLINE | ID: covidwho-1288842

ABSTRACT

A signal analysis of the complete genome sequenced for coronavirus variants of concern-B.1.1.7 (Alpha), B.1.135 (Beta) and P1 (Gamma)-and coronavirus variants of interest-B.1.429-B.1.427 (Epsilon) and B.1.525 (Eta)-is presented using open GISAID data. We deal with a certain new type of finite alternating sum series having independently distributed terms associated with binary (0,1) indicators for the nucleotide bases. Our method provides additional information to conventional similarity comparisons via alignment methods and Fourier Power Spectrum approaches. It leads to uncover distinctive patterns regarding the intrinsic data organization of complete genomics sequences according to its progression along the nucleotide bases position. The present new method could be useful for the bioinformatics surveillance and dynamics of coronavirus genome variants.


Subject(s)
Computational Biology/methods , Genome, Viral , SARS-CoV-2/genetics , Viral Proteins/genetics , Coronavirus/genetics , Humans , SARS-CoV-2/isolation & purification
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